The Carmelite Church is the only surviving medieval mendicant church in Mainz – and it is by no means just an "old ruin"! The first Carmelites
came to Mainz around 1270. The first actual monastery was built together with the church in the first half of the 14th century. In the course of secularization, the monastery was dissolved in 1802. It was not until more than a hundred years later, in 1924, that the Carmelite Church was returned to the mendicant order, which had been based in Mainz since 1270. Until then, it had been used as a storage room and was only saved from demolition by protests from Mainz citizens.
Construction of the present monastery began in 1963. Since 1964, monks have once again been living in the adjoining monastery and reviving the early 14th-century monastery church.

Despite many changes over the centuries, the Carmelite Church can still be experienced in its original state; only the ceiling paintings are copies. Among the highlights are the 14th-century high altar shrine with a bas-relief from 1517, the "Vine Madonna" (around 1400), and the modern stained glass windows by Jan Schoenaker (1970). The central choir window shows the Mainz city coat of arms and two "Mainzelmännchen" (Mainz mascots).

In 2009/2010, a major interior renovation was carried out, which included the creation of an altar island in the central area, on which a new wooden altar stands.